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Group BGD

            

  

From left to right: Sergi Hervás, Sònia Casillas, Marta Coronado, Isaac Noguera, David Castellano, Antonio Barbadilla

Researchers:

    • Sergi Hervás
    • Jesús Murga
    • Ruth Gómez
    • Esteve Sanz

 

Contact: antonio.barbadilla@uab.es

 

Key words: Population genomics, Drosophila, humans, polymorphism, divergence, natural selection, epigenomics, embryo evolution, metadimensional data integration, protein and regulatory evolution 

 

 Our research 

 

The group of the bioinformatic of genome diversity works  on the representation, analysis and interpretation of  genome variation and its relationship with phenotypic  variation. A new dimension of the studies of genetic  variation is provided by the abundance of complete  genomes that are increasingly being deciphered, and the new throughput data coming from other Omics layers, such as Encode and modEncode projects or the Epigenomic consortium for humans and model organisms. We follow an interdisciplinary approach, merging methods and knowhow from genomics, population genetics, system biology and bioinformatics, to address the following objectives: (1) Integrate population genomics data with functional data to characterize the genomic determinants of nucleotide and protein evolution; (2) Develop new theoretical population genetics models to estimate the action of selection on genome variation; (3) Analyze adaptive evolution and conservation of developmental genes which are differentially expressed in time and space for Drosophila and humans

 

 Main Reseach Lines
   
 
  • Genomics and epigenomics determinants of nucleotide and protein evolution
 
 

Previous Genome Population results from DGRP and modENCODE allow exploring at a new Omic integrative scale the relationships among functional elements and epigenomics mechanisms of genome regulation by a side, with genome and transcriptome variation, functional constraint and adaptation along the genome on the other side. 

 
   
  
  • Modeling natural selection under a general recombination framework



Recent evidence based on the patterns of genome diversity show that many loci and genome regions area affected by recurrent linked selection (genetic draft). We will develop a new general statistical approach to estimate the fraction of adaptive substitutions of any genome region regardless whether they are or are not undergoing recurrent linked selective events.

 

   
   
  
  • Mapping selection onto embryo development


 

Integrating information from population genomics data with recent knowledge on developmental genetics allow getting evidence of the evolution of embryonic development at the microevolutionary level and testing the selective importance of hierarchy in gene networks, pleiotropic interactions or preferential evolution of regulatory vs coding sequences. 


 



 

 

 

 

 

Members of the GBE Group

 

 

 

Former students 

  • Natalia Petit (PhD student)
  • Miquel Ràmia (PhD student) 
  • Maite Barrón (PhD student)
  • Isaac Noguera 
  • Esteve Sanz 

Group BGD | 





Group Bioinformatics of Genome Diversity, UAB


 


Barbadilla, A., Sònia Casillas & A. Ruiz. 2019. La teoría neutralista de la evolución molecular, medio siglo después. Investigación y Ciencia. Págs. 52-59. Febrero 2019


Marta's Doctoral Thesis Defense (18 dec 2018)

Espectacular Presentation of Doctoral thesis. Congratulations Dr. Coronado!



Sergi Hervás Thesis Defense (30 nov 2018)

We are proud of your superb presentation. Congratulations Sergi!


Jesús, Marta and Sandra's paper accepted in NAR 
Congratulations!

Murga-Moreno, J.; Coronado-Zamora, M.; Bodelón, A.; Barbadilla, A. and Casillas, S  2018. PopHumanScan: the online catalog of human genome adaptation. Nucleic Acids Research, gky959, https://doi.org/10.1093/nar/gky959 

 

Sonia and Roger's paper accepted in NAR 
Congratulations!

Casillas, S., R. Mulet, P. Villegas-Mirón, S. Hervás, E. Sanz, D. Velasco, J. Bertranpetit, H. Laayouni & A. Barbadilla. 2018. PopHuman: the human population genomics browser. Nucl. Acids Res. gkx943, https://doi.org/10.1093/nar/gkx943

Reseña del artículo (press release in english



Marta and Irepán's paper accepted in MBE 
Congratulations!

Salvador*, I., M. Coronado*, D. Castellano, A. Barbadilla & I. Salazar. 2017. Mapping selection within Drosophila melanogaster embryo’s anatomy. Molecular Biology and Evolution https://doi.org/10.1093/molbev/msx266.

Reseña del artículo (press release in english


Sergi's Paper accepted in Bioinformatics
Congratulations!

S. Hervas, E. Sanz, S. Casillas, J. Pool and A. Barbadilla. 2017. PopFly: the Drosophila population genomics browser. Bioinformatics 
doi.org/10.1093/bioinformatics/btx301

 

Sònia and Antonio's Review Paper on Molecular Population Genetics

Casillas, S. and A. Barbadilla. 2017. Molecular Population Genetics. Genetics 205: 1003–1035.


David's Paper accepted in MBE
Congratulations David!

Castellano, D., M. Coronado-Zamora, JL. Campos, A. Barbadilla, A. Eyre-Walker. 2016. Adaptive evolution is substantially impeded by Hill-Robertson interference in Drosophila. Molecular Biology and Evolution. doi:10.1093/molbev/msv236

Reseña del artículo (press release in english

 

 

Marta Coronado ganadora de la VIII edición del Premi Antoni Prevosti de Biologia Evolutiva a la millor comunicació presentada per un jove investigador.

¡Felicidades Marta!

 

Marta Coronado muestra el diploma recibido como ganadora de premio Antonio Prevosti 2015 (23 junio 2015)

Título comunicación premiada: Mapping selection onto embryo development in Drosophila


Highlights

Wilson, G., Bryan, J., Cranston, K., Kitzes, J., Nederbragt, L. & Teal, T.K. (2017Good enough practices in scientific computing. PLoS computational biology  2017  13:e1005510